氨茶碱与喷托维林对老年睡眠呼吸暂停综合征患者血清CRP、单核细胞趋化蛋白1及血清免疫因子的影响研究

摘要

目的：探讨氨茶碱与喷托维林对老年睡眠呼吸暂停综合征患者血清C反应蛋白（ CRP）、单核细胞趋化蛋白1（ MCP－1）及血清免疫因子的影响。方法收集老年睡眠呼吸暂停综合征患者112例，按照就诊先后顺序分为实验组和对照组，每组各56例，对照组患者给予盐酸罗格列酮片、三贝苎鼾胶囊，实验组患者在对照组的基础上给予氨茶碱片与枸橼酸喷托维林片。随诊3个月，比较治疗前后2组患者血清C反应蛋白（C creative protein，CRP）、单核细胞趋化蛋白1（monocyte chemotaxis protein 1，MCP－1）、白细胞介素－4（interleukin －4，IL－4）、白细胞介素－8（interleukin －8，IL－8）、白细胞介素－10（interleukin －10，IL－10）及干扰素－γ（interferon－γ，IFN－γ）。结果治疗结束后与对照组相比，实验组患者血清CRP、MCP－1、IL－8、IFN－γ水平较低（P＜0．05）；IL－4及IL－10水平较高（P＜0．05）。结论氨茶碱与喷托维林能够有效治疗老年睡眠呼吸暂停综合征及其并发症，推测其机制可能与降低患者血清CRP、MCP－1、IL－8、IFN－γ水平，升高IL－4及IL－10水平有关。%Objective To investigate the effect of aminophylline and pentoxyverine on serum CRP, monocyte chemotaxis protein 1(MCP-1) and serum immune factors in elderly patients with sleep apnea syndrome .Methods 112 elderly patients with apnea syndrome were divided into the control group and the experiment group by order of medical treatment and 56 cases in each group.The control group were treated by rosiglitazone hydrochloride tablets and bay three ramie snore capsule and the experiment group were treated on the control group with Aminophylline Tablets and Pentoxyverine Citrate Tablets.Follow up 3 months, the CRP, MCP-1,IFN-γ,IL-4,IL-8 and IL-10 were tested and compared.Results Compared with the control group after treatment, the CRP,MCP-1,IFN-γand IL-8 level were lower(P <0.05),the IL-4 and IL-10 level were higher(P <0.05).Conclusion Aminophylline and pentoxyverine can be effective in treatment of elderly patients with apnea syndrome and its complications , suggesting that the mechanism may be related to reduce the patients serum CRP, MCP-1, IL-8 and IFNγ-levels, is related to the increasing of the levels of IL-4, IL-10.