β-七叶皂甙钠对急性脑梗死患者血管内皮功能、同型半胱氨酸、超敏C反应蛋白及临床疗效的影响研究

摘要

Objective To explore β-sodium aescinate on vascular endothelial function ( FMD ) , homocysteine ( Hcy ) and hypersensitive C-reactive protein ( hs-CRP) and clinical efficacy in patients with acute cerebral infarction.Methods 198 acute cerebral infarction patients from March 2013 to April 2015 were randomly divided into observation group (n=100) and control group (n=98).Control group were treated according to the condition of the disease, observation group were treated by β-sodium aescinate base on control group, 20mg was added to 250mL saline for intravenous drip,one times per day.Continuous used 14d for one treatment courses.Compared the change of vascular endothelial function, Hcy and hs-CRP and clinical efficacy.Results The total effective rate of observation group was 90.00%, which was significantly higher than that of 71.42% in control group (χ2 =11.01,P<0.05).Post-treatment the value of FMD significantly increased, Hcy and hs CRP were significantly decreased both in observation group and control group respectively, which the difference had a statistically significant as compared with Pre-treatment (P<0.05);but, the value of FMD was significantly higher, Hcy and hs CRP was significantly lower in observation group than that of control group (P<0.05).Conclusion It has a significant β-sodium aescinate clinical effect in treatment of acute cerebral infarction, and FMD are significantly higher, Hcy and hs-CRP are significantly decrease.%目的：探讨β-七叶皂甙钠对急性脑梗死患者血管内皮功能、同型半胱氨酸及超敏C反应蛋白及临床疗效的影响。方法将保定市第二医院2013年3月～2015年4月收治的198例患者随机分为观察组（n＝100）和对照组（n＝98）。对照组根据病情给予对症治疗，治疗组在对照组的基础上给予β-七叶皂甙钠20 mg加入250 mL生理盐水进行静脉滴注，1次／天。连续使用14 d为1疗程。观察比较2组血管内皮功能（ FMD）、同型半胱氨酸（ Hcy）、超敏C反应蛋白（ hs-CRP）的水平以及临床疗效的变化。结果观察组总有效率90.00％，明显高于对照组的71.42％，2组比较差异有统计学意义（χ2＝11.01，P＜0.05）。治疗后观察组和对照组分别与治疗前相比，FMD显著升高，Hcy和hs-CRP均显著降低（P＜0.05）；但治疗后观察组与对照组相比，治疗组FMD显著高于对照组，Hcy和hs-CRP则显著低于对照组（ P＜0.05）。结论β-七叶皂甙钠治疗急性脑梗死患者临床疗效显著，患者FMD显著升高，Hcy和hs-CRP显著降低。