聚维酮碘冲洗联合左氧氟沙星滴眼液对糖尿病合并白内障患者血清及泪液中炎性指标、NO以及抗氧化指标的影响

摘要

目的：探讨聚维酮碘冲洗联合左氧氟沙星滴眼液对糖尿病合并白内障患者血清及泪液中炎性指标、NO及抗氧化指标的影响。方法以2013年1月～2015年1月收治的50例糖尿病合并白内障患者为研究对象，均接受白内障手术，随机双盲法将患者分为2组，各25例，对照组术前左氧氟沙星滴眼液干预，观察组在对照组基础上联合聚维酮碘冲洗，比较2组冲洗前后炎性指标（IL－2、sIL－2R、IL－6）、NO、抗氧化指标（TAC、SOD、CAT）及术后感染情况。结果观察组冲洗后血清及泪液中sIL－2R、IL－6、NO水平明显低于对照组（P＜0．05），IL－2、TAC、SOD、CAT明显高于对照组（P＜0．05）。观察组术后感染率为0，显著低于对照组的16．0％（P＜0．05）。结论聚维酮碘冲洗联合左氧氟沙星滴眼液能明显减轻糖尿病合并白内障患者术前炎性反应，提高其抗氧化水平。%Objective To investigate the effect of povidone iodine irrigation combined with levofloxacin eye drops on the inflammatory indexes, NO and antioxidant indices in serum and tear fluid of patients with diabetic cataract.Methods 50 cases of pati ents with diabetic cataract and admitted into the hospital during January 2013 to January 2015 were selected as the research objects all of whom received cataract surgery.According to the randomized double blind method, the patients were divided into two groups with 20 cases in each group.The control group received levofloxacin eye drops intervention before surgery while the observation group were treated withpovidone iodine irrigation, based on the control group.The inflammatory indexes (IL-2, sIL-2R, IL-6), NO, antioxidant indexes (TAC, SOD, CAT) and condition of postoperative infection were compared between the two groups before and after irrigation.ResuIts In the observation group, the sIL-2R, IL-6 and NO levels in serum and tear fluid after irrigation were significantly lower than those in the control group while IL-2, TAC, SOD and CAT were significantly higher than those in the control group.The differences were statistically significant (P<0.05).The postoperative infection rate of the observation group was 0.0% which was significantly lower than 16.0% of the control group.The difference was statistically significant ( P<0.05 ) .ConcIusion Povidone iodine irrigation combined with levofloxacin eye drops can significantly reduce the inflammatory reactions in patients with diabetic cataract and improve their antioxidant level.