活血益气润肠汤对慢性顽固性便秘患者结肠动力学的影响

摘要

目的：探讨活血益气润肠汤对慢性顽固性便秘患者结肠动力学的影响。方法选取2013年10月～2015年6月在临海市中医院接受治疗的68例慢性顽固性功能性便秘患者，随机分成2组，每组34例。2组均予合理饮食和生活习惯指导等一般治疗，对照组予以口服莫沙必利，研究组予以中药活血益气润肠汤。治疗前后检测2组血清MTL和SP水平，行Wexner便秘评分和GIQLI评分评估、结肠动力学检查，比较临床疗效。结果与治疗前比较，2组血清MTL和SP水平升高（P＜0.05），Wexner便秘评分降低（P＜0.01），GIQLI评分升高（P＜0.05），显示子RCTT、LCTT及RSTT传输时间减短（P＜0.05）；与对照组比较，研究组MTL和SP水平较高（P＜0.05），Wexner便秘评分较低（P＜0.05），GIQLI评分较高（P＜0.05），显示子RCTT、LCTT及RSTT传输时间较短（P＜0.05），临床疗效较高（P＜0.05）。结论活血益气润肠汤能改善慢性顽固性便秘患者临床症状，增强胃肠动力，提高临床疗效。%Objective To investigate the effects of Huoxue yiqi runchang decoction in the treatment of chronic intractable constipation in colonic dynamics.Methods 68 cases patients of chronic obstinate functional constipation from October 2013 to June 2016 in linhai traditional chinese medicine hospital were selected and randomly divided into two groups,34 cases in each group,two groups received reasonable diet and lifestyle guidance and general treatment, and the control group received oral mosapride,and the experiment group received more with Huoxue yiqi runchang decoction.Levels of serum MTL and SP,the score of line Wexner constipation and GIQLI,colon motility examination,and clinical efficacy were compared.Results Compared with before treatment,levels of serum MTL and SP in two groups were increased (P<0.05),score of Wexner constipation decreased (P<0.05),and score of GIQLI increased (P<0.05),and transmission time of RCTT,LCTT and RSTT decreased (P<0.05).Compared with the control group,levels of serum MTL and SP in the experiment group were higher,score of Wexner constipation were lower (P<0.05),score of GIQLI were higher(P<0.05), and transmission time of RCTT,LCTT and RSTT was lower ( P <0.05 ) , and the clinical efficacy was higher ( P <0.05 ) .Conclusion Huoxue yiqi runchang decoction can improve clinical symptoms in patients with chronic constipation, and enhance the gastrointestinal motility,and improve the clinical efficacy.