目的：探讨嗜酸乳杆菌片联合小儿腹泻贴对小儿急性腹泻患儿血清心肌酶、同工酶水平的影响。方法回顾性选取德阳市第二人民医院儿科诊断及治疗的急性腹泻患儿92例，按随机数字表法进行分组，对照组46例予以常规治疗，研究组46例予以嗜酸乳杆菌片联合小儿腹泻贴治疗，治疗前后采血测定血清心肌酶、同工酶，炎症因子及T淋巴细胞水平，同时对比临床疗效。结果对照组患儿治疗后临床有效率（82．61％）低于研究组患儿治疗后临床有效率（95．65％），差异具有统计学意义（P＜0．05）；与对照组比较，研究组治疗后血清心肌酶、同工酶均降低，治疗后血清肿瘤坏死因子α（TNF－α）、白介素－6（IL－6）、白介素－10（IL－10）水平均降低，治疗后CD3＋、CD4＋及CD4＋／CD8＋水平升高，CD8＋水平降低，差异具有统计学意义（P＜0．05）；2组患儿均未出现胃肠道不适、皮肤红肿等不良反应。结论采用嗜酸乳杆菌片联合小儿腹泻贴能降低急性腹泻患儿血清心肌酶、同工酶水平，提高免疫能力，效果显著。%Objective To investigate the effects of Lactobacillus acidophilus tablets combined with infantile diarrhea paste in the treatment of acute diarrhea in children.Methods Retrospective study of a total of 92 children with acute diarrhea from our hospital were collected and randomly divided into experimental group and control group with 46 cases in each group.Patients in the control group were treated by conventional treatment, patients in the experimental group were treated by Lactobacillus acidophilus tablets combined with infantile diarrhea paste.The serum myocardial enzyme, isozyme, inflammatory factors and the levels of T lymphocyte were determined, and the clinical efficacy before and after treatment was compared.Results The clinical effective rate of the control group ( 82.61%) was lower than the experimental group ( 95.65%) , with statistical significance ( P<0.05 );compared with the control group, after treatment the serum myocardial enzyme and isozyme of the experimental group decreased, after treatment the serum TNF-α, IL -6 and I -10 levels decreased, after treatment the CD3 +, CD4 + and CD4 +/CD8 +levels increased, CD8 + level decreased, with statistical significance ( P<0.05 ) , There was no adverse reactions such as gastrointestinal discomfort and skin irritation happened in two groups of patients.Conclusion Lactobacillus acidophilus tablets combined with infantile diarrhea paste in the treatment of children with acute diarrhea could reduce serum myocardial enzymes and isozyme levels, improve immune ability and the effect is remarkable.
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