Objective To investigate the clinical efficacy of carboprost tromethamine injection and misoprostol in high-risk of maternal postpartum. Methods 60 maternal with high-risk postpartum hemorrhage from January 2012 to January 2017 were divided into the control group and study group,30 case in each group.The two groups were treated with cesarean section surgery, the control group received misoprostol sublingual, study group were treated with carboprost tromethamine injection by intramuscular injection, recorded two groups of postpartum hemorrhage andthe incidence of adverse reactions. Results The study group of 2h postpartum hemorrhage, 24 h postpartum hemorrhage were significantly lower than control group (P<0.05); the incidence of adverse drug reactions in study group was 10.00%, and control group was 13.33%, there is no significant difference. Conclusion Carboprost tromethamine injection was effective and safe in the prevention of postpartum hemorrhage, which was beneficial to the quality of life and safety of high-risk postpartum women.%目的 探讨卡前列素氨丁三醇注射液、米索前列醇对产后出血高危产妇的临床预防效果.方法 选取台州医院恩泽妇产医院于2012年1月~2017年1月期间收治的60例产后出血高危产妇作为研究对象,随机分为对照组和研究组,每组各30例.2组均接受剖宫产手术,对照组给予米索前列醇舌下含服,研究组提供卡前列素氨丁三醇注射液肌肉注射,记录2组产妇产后出血量、不良反应发生情况.结果 研究组产后2h出血量、产后24h出血量均显著少于对照组,差异具有统计学意义(P<0.05);研究组药物相关不良反应发生率(10.00%)与对照组(13.33%)对比差异无统计学意义.结论 应用卡前列素氨丁三醇注射液预防产后出血有效性、安全性均较优,有利于保障产后出血高危产妇生活质量、生命安全.
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