葛根素注射液联合左旋多巴治疗帕金森病的临床研究

摘要

Objective To observe the clinical efficacy of puerarin injection combined with levodopa in the treatment of Parkinson. Methods 126 Parkinson patients were grouped into two groups randomly. Control group was treated with levodopa and observation group was added to Gegensu injection. Results 3 months later, UPDRS scale score, ADL and HAMD score of observation group were lower than that of control group(P<0.05).Serum Hcy and plasma hs-CRP level of observation group were lower than that of control group( P<0.05).Adverse reactions of observation group was 6.35％ during treatment, compared with the control group 9.52％ had no significant difference. Conclusion Gegensu injection can help improve cognitive ability and improve self-care ability in patients with Parkinson, alleviate symptoms and medication safety.%目的 观察葛根素注射液联合左旋多巴治疗帕金森病的临床疗效.方法 研究对象选自我院126例帕金森患者,分成2组,对照组给予左旋多巴治疗,观察组在对照组基础上加用葛根素注射液.结果 3个月后,观察组统一帕金森病评定量表(UPDRS)评分、日常生活活动能力量表(ADL)和汉密顿抑郁量表(HAMD)得分均低于对照组(均P<0.05),观察组血清同型半胱氨酸(Hcy)和血浆超敏C反应蛋白(hs-CRP)水平均低于对照组(均P<0.05).在不良反应上,观察组为6.35％,与对照组9.52％比较差异无统计学意义.结论 葛根素注射液有助于提高帕金森患者认知能力并改善患者生活自理能力,减轻患者症状,且用药安全.