当归黄芪汤加减联合蔗糖铁注射液对慢性肾功能衰竭贫血患者血清铁蛋白、叶酸水平及临床疗效的影响

摘要

Objective To investigate the effect of the serum ferritin,folic acid and its clinical efficacy by Chinese angelica Astragalus decoction combined with Iron Sucrose Injection in the treatment of the anemia patients with chronic renal failure.Methods 66 anemia patients with chronic renal failure were selected and randomly divided into the control group and the experiment group with 33 cases in each group.The control group were treated by Venofer and the experiment group were treated on the base of the control group with Chinese angelica and Astragalus Decoction.The clinical curative effect before and after treatment,serum ferritin,folic acid(SF),serum creatinine(Scr),urea nitrogen(BUN),creatinine clearance rate(Ccr),blood uric acid(UA),cholesterol(TC),total cholesterol(TG),high density lipoprotein(HDL-C)were compared after 6 months of treatment and the adverse reaction conditions was compared during the treatment between two groups.Results The effective rate of treatment in the control group was 69.70％lower than that in the observation group,the effective rate was 90.91％,with statistical significance(P<0.05).Compared with the control group,the SF and folic acid levels were lower,the Scr and BUN levels were lower,the Ccr and UA levels were higher,the TC and TG levelswere lower,the HDL-C level was higher,with statistical significance(P<0.05).Conclusion Angelica Astragalus decoction combined with Iron Sucrose Injection in the treatment of chronic renal failure patients with anemia effect is significant,can effectively reduce the level of serum ferritin and folic acid,the clinical effect is better.%目的 观察当归黄芪汤加减联合蔗糖铁注射液对慢性肾功能衰竭贫血患者血清铁蛋白、叶酸水平及临床疗效影响.方法 将66 例慢性肾功能衰竭贫血患者随机分为对照组和观察组各33 例,对照组患者予以蔗糖铁注射液治疗,观察组患者在对照组基础上联合当归黄芪汤加减治疗.比较2 组治疗6 个月后临床疗效,对比治疗前后血清铁蛋白(SF)、叶酸、血肌酐(Scr)、尿素氮(BUN)、内生肌酐清除率(Ccr)、血尿酸(UA)、胆固醇(TC)、总胆固醇(TG)、高密度脂蛋白(HDL-C)的变化,比较2 组治疗期间不良反应发生情况.结果 对照组的治疗总有效率为69.70％,观察组的治疗总有效率为90.91％,观察组明显高于对照组( P< 0.05);与对照组比较,观察组治疗后SF、叶酸水平较低,Scr及BUN水平较低,Ccr及UA水平较高,TC及TG水平较低,HDL-C水平较高,具有统计学意义( P< 0.05).结论 当归黄芪汤加减联合蔗糖铁注射液治疗慢性肾功能衰竭贫血患者效果显著,能有效降低血清铁蛋白及叶酸水平水平,临床效果更好.