加用血必清注射液对感染性休克患者外周血红细胞分布宽度、炎症介质及APACHEII评分的影响

摘要

目的 分析加用血必清注射液对感染性休克患者外周血红细胞分布宽度、炎症介质、APACHEII评分的影响,以期探寻治疗感染性休克患者最理想方案.方法 选取本院2014年5月～2015年5月治疗的感染性休克患者90例患者,将90例患者随机分为观察组和对照组,各45例,对照组患者采用感染性休克的常规治疗,观察组患者在感染性休克常规治疗的基础上联合血必清注射液,对比2组患者治疗前后红细胞分布宽度、炎症介质(IL-2、IL-4、IL-6)水平及APACHEII评分情况.结果 2组患者治疗前IL-2、IL-4、IL-6水平对比无差异,治疗后观察组患者IL-2、IL-4、IL-6水平分别为(23.5±2.3)、(21.7±3.6)、(22.5±3.4),明显低于对照组患者,2组患者治疗前红细胞分布宽度、APACHEII评分对比无差异,治疗2d后2组患者红细胞分布宽度、APACHEII评分对比无差异,治疗5d后观察组患者红细胞分布宽度(％)、APACHE II评分分别为(9.8±1.7)、(10.4±1.9),明显低于对照组患者,治疗前2组患者CO、CI、SVR、EVLWI对比无差异,治疗2d后2组患者CO、CI、SVR、EVLWI对比无差异,治疗5d后观察组患者CO、CI分别为8.9±1.4)、(9.3±2.1),明显高于对照组患者,而SVR、EVLWI水平为(865.7±104.5)、(5.7±0.9)低于对照组患者.结论 常规治疗加用血必清注射液可以降低感染性休克患者外周血红细胞分布宽度及炎症介质水平,降低APACHEII评分,临床效果更好,治疗方案更理想.%Objective To study the effect of blood biqing1 injection on patients with septic shock in peripheral blood red cell distribution width,inflammatory mediators and APACHEII score.Methods 90 patients with septic shock in our hospital from May 2014 to May 2015 were randomLy divided into observation group and control group,each of 45 cases,the control group was treated with conventional treatment of septic shock,blood in patients in the observation group on the basis of routine treatment of septic shock biqing1 injection,before and after comparison two groups of red cell distribution width and inflammatory mediators(IL-2,IL-4,IL-6)level and APACHEII score.Results Two groups of patients before treatment,IL-2,IL-4 and IL-6 levels compared to no difference after treatment,the observation group were IL-2,IL-4,IL-6 levels were(23.5±2.3),(21.7 ±3.6),(22.5±3.4),significantly lower than the control group patients,two groups of patients before treatment,red cell distribution width,APACHEII score comparison showed no difference in treatment of 2D two groups of patients after the red cell distribution width and APACHEII score compared to no difference after the treatment of 5D,observation group distribution in red blood cell width(％),APACHE II score were(9.8±1.7),(10.4±1.9),significantly lower than the control group patients,two groups were CO,CI,SVR,EVLWI compared to no difference before treatment.After the treatment of 2D patients in the two groups CO,CI,SVR,EVLWI compared to no difference after the treatment of 5 days patients in the observation group,CO,CI were(8.9±1.4),(9.3±2.1),significantly higher than the control group,while the level of SVR and EVLWI were(865±104.5),(5.7±0.9),significantly lower than the control group.Conclusion Will the blood injection can reduce septic shock in patients with peripheral blood red cell distribution width and the levels of inflammatory mediators,reduce the score of APACHEII.