目的 探讨优甲乐治疗妊娠期甲减患者的临床疗效及对TSH、FT3、FT4水平的影响.方法 选取2014年6月~2015年6月温州市中西医结合医院接诊的100例妊娠期甲减患者作为本次研究对象,随机分为对照组和观察组.对照组采用附桂地黄丸治疗,观察组在对照组基础上加用优甲乐治疗,观察2组患者治疗后TSH、FT3、FT4水平,妊娠结局,新生儿不良结局及治疗疗效.结果 治疗后,观察组TSH水平低于对照组,FT3、FT4水平高于对照组,差异具有统计学意义(P<0.05);观察组妊娠并发症总发生率低于对照组[12.00%(6/50)vs 40.00%(20/40)](P<0.05);观察组新生儿不良结局总发生率低于对照组[8.00%(4/50)vs 26.00%(13/50)](P<0.05);观察组治疗总有效率高于对照组[96.00%(48/50)vs 80.00%(40/50)](P<0.05).结论 优甲乐治疗妊娠期甲减的疗效显著,能够改善TSH、FT3、FT4水平,缓解临床症状.%Objective To study curative efficacy of euthyrox in treatment of hypothyroidism during pregnancy and its effect on levels of TSH , FT3 and FT4.Methods 100 patients of hypothyroidism during pregnancy who received therapy from June 2014 to June 2015 in our hospital were selected as research objects, and divited into control group and observation group,50 cases in each group.The control group was treated with Fugui Dihuang wan, while the observation group was treated with euthyrox on the basis of control group.Then the levels of TSH,FT3 and FT4, pregnancy outcome, neonatal adverse outcome, treatment outcome of two groups after treatment were compared.Results After treatment, the level of TSH in observation group was lower than the control group, the levels of FT3 and FT4 was higher than the control group ( P<0.05 ); Incidence of pregnancy complications in observation group was less than the control group [12.00%(6/50)vs 40.00%(20/40)](P<0.05);Total neonatal adverse outcomes [8.00%(4/50) vs 26.00%(13/50)](P<0.05); The total effective rate of observation group was statistically higher than that in the control group [96.00%(48/50) vs 80.00%(40/50)](P<0.05).Conclusion Euthyrox is well for hypothyroidism during pregnancy, which can improve TSH, FT3 and FT4 levels, relieve clinical symptoms.
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