闭眼和睁眼脑电图脑能量对听觉诱发电位P300的影响

摘要

目的 探讨静息闭眼及睁眼脑电图(EEG)脑能量对听觉诱发电位P300的影响.方法 招募12名健康男性在校大学生(20～24岁),分别在其闭眼及睁眼时先记录2minEEG,然后进行听觉P300实验.结果 ①Alpha波主要分布在顶枕区,Alpha-1 (7.5～ 9.5 Hz)区域能量[闭眼(2.62±0.81)μV2,睁眼(1.81±0.56) μV2],差异有显著性(P＜0.01)；Alpha-2( 10～12 Hz)区域能量[闭眼(8.55±1.85) μV2,睁眼(4.95±1.59) μV2],差异有显著性(P＜0.05).②P300实验标准刺激诱发电位以N1(90ms)及P2(180 ms)成分为主,闭眼和睁眼差异无显著性；新异刺激诱发电位以N2(207 ms)及P3(313 ms)成分为主,N2区域电位闭眼[(0.01±0.71)μV]较睁眼[(-2.13±0.80)μV]减小,差异显著(P＜0.01)；P3区域电位闭眼[ (4.16±1.08) μV]较睁眼[(4.78±1.20)μV]减小,差异无显著性.结论 静息闭眼状态Alpha区域能量明显高于睁眼,而在听觉诱发电位P300范式N2区域负向电位明显小于睁眼状态.%Objective To investigate the effects of eyes-closed (EC) and eyes-open (EO) EEG field powers on the auditory P300 evoke potentials.Methods The EEG was recorded in 12 healthy male college students (20 ～24 years) respectively in their eyes-closed and eyes-open states,and then the auditory P300 paradigm was performed.Results ① Alpha band was distributed at the posterior-occipital area,while Alpha-1 (7.5～9.5 Hz) field power were EC as (2.62 ±0.81 ) μV2 and EO as ( 1.80 ±0.56) μV2,with statistical significance (P ＜ 0.01 ) ; Alpha-2 ( 10 ～ 12 Hz) field power were EC as ( 8.55 ± 1.85 ) μV2 and EO as (4.95 ± 1.59 )μV2,also with statistical significance (P＜0.05).②In P300,the Common stimulus elicited clear component N1 (90ms)and P2 (180ms) in the ERPs after stimulus,while there were no significant differences between EC and EO states.Correspondingly,the rare stimulus elicited clear component N2 (207 ms) and P3 (313 ms) in the ERPs after stimulus on-set.Comparing the differences of field potentials of the rare stimulus between the two states,N2field potential in EC ( (0.01 ± 0.71 ) μV) was smaller than that in EO ( ( - 2.13 ± 0.80 ) μV ),with statistical significance (P ＜ 0.05 ) ; while P3 field potential in the EC ( ( 4.16 ± 1.08 ) μV ) was smaller than that in EO ( (4.78 ± 1.20) μV),but without statistical significance (P ＞ 0.05 ).Conclusion The alpha field power is higher in eyes-closed than in eyes-open state,while performing the same auditory P300 paradigm,significant reduction of field potential in the N2 component are observed in eyes-closed than in eyes-open state.