月经病虚寒证患者T细胞亚群与生殖激素的变化

摘要

目的:通过分析虚寒型月经病患者外周血T细胞亚群与生殖激素水平的变化及二者的相关关系,探讨妇科虚寒证的内分泌-免疫学发病机理.方法:分别采用放射免疫分析法和流式细胞技术检测虚寒型月经病患者、正常人各30例生殖激素与T细胞亚群的变化,分析其相关性.结果:虚寒组较正常组E”T、LH、FSH、及Th2、Th2/Th1、Tc2、Tc1、Tc2/Tc1降低,Th1升高,均有统计学意义.Th2、Th2/Th1与E2呈正相关,Th1与E2呈负相关；Th2、Tc2、Th2/Th1与T呈正相关；Th1与FSH呈负相关.结论:月经病虚寒证患者生殖激素分泌减少,Th2、Tc2、Tc1细胞水平下降,Th1细胞水平上升,机体内分泌-免疫调节功能紊乱而发生月经病.%Objective:By analyzing the changes ofrelations between type Ⅰ and type ⅡT lymphocytes and reproductive hormone in menopathy of asthenia cold syndrome patients,and the relations between them,initially approach partly etiopathogenesis of it from endocrine-immunological means.Methods:Adopt radio immunoassay and flow cytometry to respectively detect reproductive hormone and type Ⅰ and type Ⅱ T lymphocytes of thirty asthenia cold syndrome patients and health adults,analyze relations between them.Results:Compared with normal group,contents of E2 、T、LH、FSH were decreased,had statistically significant.The percentage of Th2、Th2/Th1 、Tc2、Tc1 、Tc2/Tc1 decreased,Th1 increased.The level of Th2、Th2/Th1 and E2 was a positive linear correlation,Th1 and E2 was a negative linear correlation ;Th2、Tc2、Th2/Th1 and T was a positive linear correlation,Th1 and FSH was a negative linear correlation.Conclusion:Reproductive hormone of menopathy of asthenia cold syndrome patients were lower,the percentage of Th2、Tc2、Tc1、Tc2/ Tc1 decreased,Th1 increased,organism endocrine-immunological modulation function disordered,finally caused menopathy.