邻氯苯甲腈的新合成法

摘要

以邻氯溴苯为起始原料,选用K4[Fe(CN)6]为氰基化试剂,Pd/C催化反应制得邻氯苯甲腈.考察了温度、碱、催化剂的用量和原料比等对反应的影响,确定了较佳反应条件.邻氯溴苯转化率达98.5％,产物邻氯苯甲腈得率95.1％.%o-Chlorobenzonitrile was prepared from the cyanization reaction of o-chlorobromobenzene using potassium ferrocyanide as cyanating agent and Pd/C as a catalyst.The reaction conditions were optimized through investigating the reaction temperature,base,the amount of catalyst,the ratio of reactants.The conversion of the o-chlorobromobenzene to target product could reach 98.5％ and the yield of o-chlorobenzonitrile was 95.1％.