超声法合成3,4-二甲氧基-4′-羟基查尔酮

摘要

3,4-Dimethoxy-4'-hydroxychalcone was synthesized by the ,Claisen-Schmidt condensation using 3,4-dimethoxybenzaldehyde and 4'-hydroxyacetophenone as reagents with ultrasonic radiation and dry HCl(g) as catalyst. The structure of the product was confirmed by IR and 1H NMR. The optimized synthesis conditions were to use anhydrous ethanol as the solvent, reaction temperature of 30 ℃ , ultrasonic radiation of 240 W, and radiation time of 20 min. A yield of 92. 1% was obtained for the reaction with 1:1 stoichiometric ratio for the starting materials. Compared with previous method in the literature, the present procedure requires a shorter reaction time, and has easier work-up and higher yield.%以3,4-二甲氧基-苯甲醛和对羟基苯乙酮为原料,无水乙醇为溶剂,HCl气体为催化剂,在超声作用下,经Claisen-Schmidt缩合反应合成了3,4-二甲氧基-4′-羟基查尔酮.产物结构经IR和1H NMR进行了表征,在2种原料摩尔比1∶1投料比条件下,优化的合成条件为超声输出功率240W,反应温度30℃,反应时间20min,产率达到92.1％,比传统方法反应时间短、操作简便、产率高.