禽白血病/肉瘤病毒肿瘤基因及其与致肿瘤机制的关系

摘要

Avian leukosis/sarcoma viruses were divided into two categories according to the difference of the activated oncogenes. Non-acute transforming virus can cause tumors by insertional activation of cellular proto-oncogene with a long latency, while acute transforming virus can induce a fast tumorigenesis through direct transcription of viral oncogene. This paper will review the relationship between the oncogenesis mechanism and oncogenes.%根据致瘤机制的差异,禽白血病/肉瘤病毒可以分为两大类,其差异主要在于所表达肿瘤基因的不同.慢性转化型病毒通过插入启动机制间接激活细胞原癌基因,肿瘤形成速度缓慢；急性转化型病毒则是直接转录表达病毒自身基因组中的病毒肿瘤基因,从而诱导肿瘤的快速形成.作者拟对禽白血病/肉瘤病毒肿瘤基因及其与致肿瘤机制的关系进行综述.