重组禽流感病毒灭活疫苗（H5N1亚型）对鸭和鹅的免疫效果观察

摘要

由H5N1亚型禽流感病毒（Avian influenza virus，AIV）引起的高致病性禽流感（highly pathogenic avian influenza， HPAI）是禽类的一种烈性传染病，疫苗免疫是禽流感防控中的重要环节。本试验采用重组禽流感病毒灭活疫苗（H5N1，Re-5株）和重组禽流感病毒H5亚型二价灭活疫苗（H5N1、Re-5株+Re-4株）进行了鸭和鹅的免疫试验，对免疫鸭和鹅的抗体水平进行了动态监测。试验结果表明，两种疫苗对鸭和鹅均具有良好的免疫效果。基于试验结果提出了鸭和鹅禽流感免疫程序：2 w左右首免，4~5 w时二免，开产前三免，此后每隔4~5个月加强免疫一次。%Highly pathogenic avian influenza (HPAI) is caused by H5N1 subtype of avian influenza virus (AIV), and the vaccination plays a key role in prevention and control. In this study, ducks and geese were immunized with either inactivated avian influenza vaccine (H5N1 subtype, Re-5 strain) or bivalent inactivated avian influenza vaccine (H5N1 subtype, Re-5 strain+Re-4 strain) and hemagglutination inhibition (HI) antibody levels were detected. Both vaccines induced strong immune responses in ducks and geese. Based on these results, the proposal for the AIV vaccination program in ducks and geese should include the initial dose at 2-week-old, the second dose at 4-5-week-old, the third dose before the beginning of laying period, and further boosters at every 4-5 month interval.