细菌非编码小 RNA 的分类及功能简介

摘要

细菌非编码小 RNA（non-coding small RNA，简称 sRNA）是一类长度为40~500个核苷酸，在基因组中被转录但不编码蛋白质的一类 RNA 分子。它们大多数在 Hfq 的协助下，通过碱基配对识别靶标 mRNA，在转录后水平调节基因的表达，是细菌代谢、群体感应和适应环境变化及毒力基因表达的重要调节因子。本文对 sRNA 的分类及功能作如下综述。%Non-coding RNAs in bacteria (sRNAs) are RNAs of about 40-500 nucleotides that transcribe but don't encode proteins. Most of these sRNAs act through base-pairing with target mRNAs with help of Hfq, resulting in post-transcriptionally regulating gene expression. Therefore, sRNAs are important regulators in bacterial metabolism, quorum sensing, adaption to environmental change and virulence gene expression.