甘草原液和寡肽修护蚕丝面膜联合治疗颜面再发性皮炎疗效观察

摘要

目的:评价甘草原液和寡肽修护蚕丝面膜联合治疗颜面再发性皮炎的疗效.方法:选取2016年10月-2017年3月至笔者科室就诊的40例颜面再发性皮炎患者为研究对象,随机分为联合组和单用组.联合组:19例,甘草原液和寡肽修护蚕丝面膜联合使用;单用组:21例,甘草原液单一使用.两组均口服枸地氯雷他定片8.8mg,每日1次,共30d.于使用前、首次使用后第10天、第20天、第30天,采用敏感型皮肤和耐受型皮肤的比较表对患者进行敏感性评估.同时于使用前、首次使用后第10天、第20天、第30天进行临床症状及体征评分比较.结果:两组患者在首次使用后第10天,敏感性评分降低不明显;首次使用后第20天敏感性评分明显降低,差异具有统计学意义(P<0.05);首次使用后第30天,敏感性评分继续降低,所有患者均由非常敏感性皮肤变为轻度敏感性或是耐受性皮肤.相较于治疗前,两组患者症状、体征都得到明显缓解,并且治疗时间越长,缓解越明显.两组患者在红斑、灼热感、瘙痒感的缓解上疗效相当,差异无统计学意义(P>0.05),但对于干燥、鳞屑的缓解,联合组明显优于单用组,差异具有统计学差异(P<0.05).在总体治疗效果上,两组均有较好的治疗效果,差异无统计学意义(P>0.05).治疗结束后随访1个月,联合组有2例复发,单用组有3例复发.结论:甘草原液和寡肽修护蚕丝面膜联合治疗颜面再发性皮炎安全、有效,值得临床推广应用.%Objective To study the effect of desloratadine citrate disodium combination with liquorice extacte and rhEGF repair silk mask on facial recurring dermatitis. Methods From October of 2016 to March of 2017,We selected 40 patients in our hospital outpatient clinic,who were suffered from facial recurring dermatitis. We divided those patients into two groups randomly,the joint group was given liquorice extacte and rhEGF repair silk mask,the single group was given liquorice extacte only,two groups of patients took desloratadine citrate disodium,one time a day,8.8mg every time.We assessed the sensitivity of patients with the comparison table of the sensitive and tolerance skin before treatment,10 days、20 days、30 days after treatment.at the same time,comparing the clinical signs and symptoms score. Results The decrease of sensitivity scores was not obvious at 10 days after treatment, the decrease of sensitivity scores was obvious at 20 days after treatment,the difference was statistically significant(P<0.05),the sensitivity scores continued to decrease and all patients were changed from very sensitive skin to mildly sensitivity skin or tolerable skin;the symptoms and clinical signs of all patients were significantly relief compared with before treatment,the longer time to treat, the more obvious relief of symptoms and clinical signs,two group patients were with similar clinical curative effect on the ease of the lupus,burning and itching,the difference was not statistically difference(P>0.05),the joint group was superior to the single group on the ease of the dryness,scale,the difference was statistically significant (P<0.05). On the overall treatment effect,two groups all had good treatment effect,the difference was not statistically difference(P>0.05). Following-up: After stopping treatment,we continued to follow-up for 1 month,two cases of patients were with recurrence in the joint group and three cases in the single group. Conclusion Using desloratadine citrate disodium combination with liquorice extacte and rhEGF repair silk mask to treat facial recurring dermatitis is safe and effective,it is worth being spreaded.