新生儿先天性甲状腺功能低下症的超声表现

摘要

Objective:To observe the ultrasonic diagnosis of neonatal congenital hypothyroidism (CH),and to explore its rela-tionship with thyroid-related hormone. Methods:100 cases of normal control group and 154 cases diagnosed as CH were exam-ined by ultrasound,and the data were analyzed. Results:There were 84 cases (54.55%,84/154) with thyroid glands diffusely enlarged and blood flow increasing significantly,34 cases (22.08%,34/154) with normal thyroid glands,24 cases (15.58%,34/154) with ectopic or athyrotic thyroid glands,and 12 cases (7.79%,12/154)with thyroid dysplasia. There was significant differ-ence of 154 CH infants between the thyroid morphological categories and thyroid hormones (TSH,FT4,FT3,P<0.05). There was no difference between thyroid volume and TSH or FT3 (P>0.05),while negative correlation between thyroid volume and FT4 (r=-0.361,P=0.004),except for the ectopic or athyrotic thyroid group. Conclusion:Thyroid ultrasound examination has a certain clinical value for finding the cause,choosing the treatment options and neonatal screening for CH.%目的：观察新生儿甲状腺功能低下症（congenital hypothyroidism，CH）的超声表现，探讨其与甲状腺相关激素水平的关系。方法：对100例正常对照组及154例确诊为CH的新生儿行甲状腺超声检查，并分析其影像资料。结果：154例中84例（54.55%）甲状腺明显肿大、血流信号明显增加；34例（22.08%）甲状腺基本正常；24例（15.58%）甲状腺异位或缺如；12例（7.79%）甲状腺发育不全。血清甲状腺TSH、FT4、FT3值在不同形态甲状腺间差异均有统计学意义（均P<0.05）；CH（甲状腺异位或缺如除外）患儿甲状腺体积与TSH、FT3不相关（P>0.05），与FT4水平呈负相关（r=-0.361，P=0.004）。结论：甲状腺超声在寻找CH病因、选择合理治疗方案和CH筛查方面具有一定的临床价值。