体素内非相干性运动DWI在糖尿病患者足部软组织灌注分析中的运用

摘要

Objective:To investigate the application of intravoxel incoherent motion (IVIM) in soft tissue perfusion of diabetic foot. Methods:Twenty healthy people were selected as group A,20 diabetic patients as group B,20 diabetic foot patients as group C. 11 different b values were used for DWI. Metacarpophalangeal,palmar flexor digitorum muscle region were measured for ROI,and the obtained image IVIM perfusion analysis were obtained. D value,D* value,f-value map were statistical analyzed and compared,D on behalf of the voxel water molecules within the real diffusion,known as the true diffusion coefficient;D* on behalf of the voxel microcirculation,called the pseudo-diffusion coefficient,f the perfusion fraction represents voxel microcircula-tion effect of the overall diffusion effect of the volume rate. Results:The D value of group B was higher than that of group A, and the D value of group C was higher than that of group B (all P<0.05). The D* values of group B was significantly lower than that of group A,and the D* value of group C was lower than that of group B (all P<0.05). The f value of group B was higher than that of group A,and the f value of group C was significantly higher than that of group B (all P<0.05). Conclusion:IVIM analysis of perfusion of diabetic patients indicates that microcirculation perfusion become worse when the D* value de-creases,which is helpful in assessing the condition of diabetes,and the D* value of diabetic foot is more pronounced.%目的:探讨体素内非相干性运动DWI(IVIM-DWI)在糖尿病患者足部软组织灌注分析中的应用.方法:选取20例健康人作为A组,选择20例糖尿病患者作为B组,另选择20例糖尿病足患者作为C组.使用11组b值行DWI,以第一跖骨掌侧、趾长屈肌肌腹区为ROI分别测量,并将所得图像行IVIM灌注分析,分别得出真性扩散系数(D)值、假性扩散系数(D*)值、灌注分数(f)值图,并进行统计学分析.结果:B组D值高于A组,C组高于B组(均P<0.05);B组D*值低于A组,C组低于B组(均P<0.05);B组f值高于A组,C组高于B组(均P<0.05).结论:IVIM对糖尿病患者的灌注情况分析显示,D*值下降,提示微循环灌注情况变差,且糖尿病足患者D*值下降更明显,对评估糖尿病病情有帮助.