Synthesis of Eu(Ⅲ) and Tb(Ⅲ) complexes with novel pyridine dicarboxylic acid derivatives and their fluorescence properties

摘要

Starting from pyridine-2,6-dicarboxylic acid (DPA),a series of novel pyridine-2,6-dicarboxylic acid derivatives were synthesized.In these compounds,4-(hydroxymethyl)pyridine-2,6-dicarboxylate (4-HMDPA) and 4-[(bis-carboxymethyl-amino)-methyl] -pyridine-2,6-dicarboxylic acid (4-BMDPA) were used as multifunctional ligands to coordinate with Tb(Ⅲ) and Eu(Ⅲ) and the complexes were prepared.The fluorescence properties of the solid complexes and their solutions were investigated in detail.The results indicated that the weak election-withdrawing group 4-hydroxymethyl in 4-position of pyridine in 4-HMDPA could weaken the fluorescence intensity of the lanthanide complexes.The contradistinctive experimental results showed that the fluorescence intensities of these complexes are related to pH values of the aqueous solutions and the dipole moments of solvent molecules:in the neutral aqueous solutions,the fluorescence intensities of these complexes were strongest,while the dipole moments were lower when the fluorescence intensifies were stronger.4-BMDPA is the better sensitizer and may be used as time-resolved fluoroimmunoassay.