子痫前期患者胎盘组织中核转录因子-κB和肿瘤坏死因子-α的表达及其临床意义

摘要

Objective To investigate the expression and its significance of the nuclear factor kappa B ( NF - κB ) and tumor necrosis factor - α ( TNF - α ) in placenta of patients with preeclampsia. Methods The expression of the NF - κB and TNF - αwas detected in placenta of 20 cases of mild preeclampsia, 20 cases of severe preeclampsia and 20 cases of normal pregnancy, respectively. Results There were increased expression of NF - κB and TNF - αin preeclampsia compared to those in normal pregnancy ( P ＜ 0. 01 ), furthermore the expression of NF - κB and TNF - α have increasing tendency with aggravation.The expression of NF - κB and TNF - αin placenta of normal pregnanc:y and preeclampsia was positively correlated. Conclusion The NF - κB and TNF - αmay play important role in the process of vascular endothelium activation and damage , so might be important causes of pathogenesis of preeclampsia.%目的 探讨核转录因子-κB (NF-κB)和肿瘤坏死因子(TNF-α)在子痫前期患者胎盘组织中的表达及其临床意义.方法 分别检测子痫前期轻度患者、子痫前期重度患者和正常妊娠孕妇(各20例)胎盘组织中NF-κB和TNF-α的表达情况.结果 NF-κB和TNF-α在子痫前期轻度、子痫前期重度患者组织中的表达均较正常妊娠孕妇明显升高(P＜0.01),且随着子痫前期病情加重其表达增强.在正常妊娠和子痫前期胎盘组织中NF-κB和TNF-α的表达强度呈正相关.结论 NF-κB和TNF-α在血管内皮细胞激活和损伤中发挥重要作用,可能是子痫前期发生、发展的重要因素.