降低磷负荷预防随年龄进展的动脉硬化研究进展

摘要

当前的研究发现血浆中磷的水平增加与动脉硬化密切相关,高磷负荷成为心血管疾病的一个独立危险因素.动脉硬化可导致血管僵硬度增加、收缩期高血压和左心室肥厚,进一步导致心力衰竭、脑卒中及肾衰竭等疾病.研究认为高磷负荷与饮食和随年龄增加的肾功能减退相关.磷在动脉硬化的发展过程中起到了多重作用.如果减少磷的摄取,将减缓动脉僵硬的进展,并可能因此在心血管死亡率及发病率上得到很大的益处.%In current research we find that the increase of phosphate density was related to Arteriosclerosis. Serum phosphate is increasingly being recognized as a cardiovascular risk factor. Arteriosclerosis can cause arterial stiffness , consequent systolic hypertension and left ventricular hypertrophy. And it can then increase the risk of heart failure , stork and kidney failure.This viewpoint suggests that the consumption of a phosphate - rich diet. exacerbated hy the high prevalence of chronic kidney disease found in ageing populations , accelerates the development of arteriosclerosis. The phosphate may have multiple influence in increasing vascular stiffness and calcification. It is hypothesized that reducing phosphate intake will attenuate the progression of arterial stiffness with major beneficial effects upon cardiovascular mortality and morbidity.