抗环瓜氨酸肽抗体检测在类风湿性关节炎诊断中的临床价值研究

摘要

Objective To explore the value of detection of anti - cyclic citndlinated peptide (anti - CCP) antibodies in the diagnosis and treatment of rheumatoid arthritis ( RA) . Methods The level of anti - CCP and RF of 41 RA patients and 85 non - RA patients were respectively detected using microparticle enzyme immunoassay method ( MEIA) and immune nephelome-try. Results The specificity and sensitivity of anti - CCP in detecting RA were 94. 1% and 65. 9% , respectively, and those of RF were 82. 3% and 85. 4% , respectively. The specificity of anti -CCP was higher than that of RF, and the sensitivity of RF was higher than that of anti - CCP (χ2 = 5. 67、4. 23, P < 0. 05) . Conclusion Anti - CCP has lower sensitivity but higher specificity than RF in detecting RA, therefore, the combination of anti - CCP and RF are suggested to raise the diagnostic accuracy of RA.%目的 探讨定量检测抗环瓜氨酸肽抗体(anti-CCP)对类风湿性关节炎(RA)诊疗的应用价值.方法 分别检测41例RA患者及85例非RA患者的anti-CCP及类风湿因子(RF)含量,其中anti-CCP采用微粒子酶免分析法(MEIA)检测,RF采用免疫散射比浊法检测.结果 anti-CCP诊断RA的特异度和敏感度分别为94.1％、65.9％,RF诊断RA的特异度和敏感度分别为82.3％、85.4％.二者在特异度和敏感度方面差异均有统计学意义(x2值分别为5.67、4.23,P＜0.05).结论 anti-CCP相对于RF指标敏感度稍低而特异度较高,建议联合检测anti-CCP和RF,提高诊断RA的敏感性和特异性.