中国老年高血压病及其并发症与血管紧张素转化酶基因多态性相关性的Meta分析

摘要

目的 探讨中国老年人群高血压病发生及其并发症与血管紧张素转化酶(ACE)基因插入/缺失(D/I)多态性的关系.方法 运用计算机和手工检索的方法,全面检索有关中国老年人群高血压病发生及其并发症与ACE基因多态性相关性的病例对照研究,运用Stata 11.0软件进行Meta分析,根据异质性检验结果分别采用随机和固定模型进行评价.结果 共纳入8项研究1 296例研究对象.荟萃分析显示ACE基因型与中国老年高血压病发病无相关性(P=0.419),但DD基因型可显著提高老年人群高血压病并发症的发生(P=0.000).结论 ACE基因变异对于中国老年高血压病并发症的发生具有明确的意义,DD基因型是中国老年高血压病并发症发生的危险因素.%Objective To investigate the correlation of hypertension and its complications with angiotensin - converting enzyme ( ACE ) gene polymorphisms in Chinese elders. Methods Case - control studies on correlation of hypertension and its complications with ACE gene polymorphisms in Chinese elders were searched by computer and manual searching. Meta - analysis and random - model/fixed - model were carried out with software Stata 11.0. Results Eight studies involving 1 296 subjects were included in this meta - analysis. There was no correlation between hypertension and ACE gene polymorphisms in Chinese elders ( P = 0. 419 ), while DD genotype was positively correlated with the incidence of hypertension complications ( P = 0. 000 ). Conclusion DD genotype of ACE gene is a risk factor for complications among Chinese elderly hypertension patients.