最小临床重要差值在 COPD 生存质量测评工具中的应用

摘要

生存质量量表／问卷等测评工具日益被应用于COPD患者的临床疗效评价，而对测评工具评分的解释和判定尤为重要。根据统计学差异去判定疗效已显示出其局限性，采用最小临床重要差值（ MCID）判断测评工具的分值改变是否具有临床重要意义逐渐受到重视。本文介绍了MCID的常用测量方法，包括效标法、分布法、文献分析法和专家意见法，重点论述各方法在不同测评工具中的具体应用，探讨测量方法、患者人口统计学特征和基线资料、患者能力及研究周期等对MCID评估的影响。%Assessment tools , including quality of life scale or questionnaire , are increasingly being used in COPD clinical evaluation , thus it′s very important to interpret and judge the value of these tools .To determine efficacy according to statistical differences has shown its limitation .Minimal clinically important difference ( MCID) is obtaining increasing attention , for it determines whether the change of evaluation tool scores holds clinically important value .In this article, we introduced the common MCID measurement methods , including anchor -based methods , distribution based methods , document analysis and expert perception , and focused on the methods in the application of various assessment tools .We came to the collusion that MCID assessment may be influenced by assessment methods , demographic characteristics of patients , baseline data , patients′ability and research cycle .