尿道下裂流行病学及其危险因素的研究现状

摘要

尿道下裂居于常见的男性先天性生殖器畸形第2位,近20 ～ 40年,全世界范围发病率报道不一,其病因及发病机制尚不明确,且存在地理、区域及种族差异.目前绝大多数相关研究数据来自国外,国内尿道下裂流行病学及其危险因素的调查研究相对匮乏.本文就尿道下裂流行病学及其危险因素的研究现状做一综述,旨在为今后该领域的继续研究提供帮助.%Hypospadias is the second most common malformation of the male genitalia.In recent 20 to 40 years,there are conflicting reports about the overall morbidity of hypospadias worldwide,and the etiology and pathogenesis are not fully clear.Moreover,there are geographical,regional and ethnic differences in the prevalence of hypospadias.At present,most of the research data are from abroad.In contrast,the investigation of epidemiology and risk factors is lacking domestically.In this article,the research status of epidemiology and risk factors of hypospadias were reviewed,in order to provide an assistance for future research in this field.