中性粒细胞明胶酶相关脂质运载蛋白与心血管疾病相关性的研究进展

摘要

心血管疾病(CVD)严重危害公众健康,因此,研究具有CVD预测价值的标志物具有重要意义.中性粒细胞明胶酶相关脂质运载蛋白(NGAL)是近年发现的重要的CVD标志物.研究发现,NGAL直接参与CVD的发病,且可独立预测急性心肌梗死(AMI)和心力衰竭(HF)的预后.本文分别对NGAL与冠心病(CHD)、AMI、HF的新近研究进行归纳和分析,发现NGAL在评估CVD的病情严重程度及预测CVD的预后方面具有临床应用价值.%Cardiovascular disease(CVD)seriously endangers public health.Therefore,it is of great significance to study the predictive markers of CVD.Recent studies showed that neutrophil gelatinase-associated lipocalin (NGAL) is an important marker for CVD.NGAL is directly involved in the pathogensis of CVD,and it also can independently predict the prognosis of acute myocardial infarction(AMI)and heart failure (HF).In this paper,the recent studies on NGAL and coronary heart disease (CHD),NGAL and AMI,NGAL and HF were respectively summarized and analyzed.We concluded that NGAL has clinical value in evaluating the severity of CVD and predicting the prognosis of CVD.