远隔缺血后适应治疗对缺血性脑卒中患者神经功能保护作用的临床研究

摘要

Objective To investigate the effect of remote ischemic postconditioning(IP) on the improvement of neurological function of patients with ischemic stroke.Methods We enrolled 200 cases of ischemic stroke from Department of Neurology,Harrison International Peace Hospital in Hengshui between January 2016 and June 2017.Using random number table,we divided them into the experimental group(n=100) receiving basic drug treatment combined with IP and control group(n=100) receiving basic drug treatment alone.The National Institutes of Health Stroke Scale (NIHSS) scores and the incidence of lateralization were recorded in the two groups before and 12 months after treatment.Results The NIHSS score was similar in both groups before treatment(P>0.05),but it was significantly decreased in the experimental group after 12-month treatment〔(13.3±2.1)scores vs. (15.2±1.8)scores〕(P<0.05).There was no significant difference in the incidence of lateralization between the two groups before treatment (P>0.05),and the incidence of lateralization in the experimental group was higher than that of the control group after 12 months of treatment(P<0.05).Conclusion IP could significantly improve the neurological function and promote the development of collaterals in the cerebral circulation,which is worth popularizing in clinical practice.%目的 探讨远隔缺血后适应治疗对缺血性脑卒中患者的神经保护作用.方法 选择衡水市哈励逊国际和平医院神经内科2016年1月—2017年6月收治的200例缺血性脑卒中患者,依据随机数字表法分为试验组(n=100)和对照组(n=100).对照组仅采用基础药物治疗,试验组采用基础药物治疗加远隔缺血后适应治疗.记录两组治疗前及治疗12个月后美国国立卫生研究院卒中量表(NIHSS)评分及偏利现象发生率.结果 治疗前试验组与对照组NIHSS评分比较,差异无统计学意义(P>0.05);治疗12个月后试验组NIHSS评分〔(13.3±2.1)分〕较对照组〔(15.2±1.8)分〕明显降低(P<0.05).治疗前两组偏利现象发生率比较,差异无统计学意义(P>0.05);治疗12个月后试验组偏利现象发生率高于对照组(P<0.05).结论 远隔缺血后适应治疗能够明显提高缺血性脑卒中患者神经功能水平,促进侧支循环建立,具有神经保护作用,值得在临床中推广应用.