复方丙酸氯倍他索软膏治疗苔藓样皮肤淀粉样变病疗效观察

摘要

目的：观察复方丙酸氯倍他索软膏治疗苔藓样皮肤淀粉样变病的疗效和安全性.方法：选取皮损位于双侧小腿且左右侧基本对称的38例患者，左侧皮损设为治疗组，右侧皮损设为对照组，分别外用复方丙酸氯倍他索软膏、0.025%全反式维甲霜，连续用药4周.结果：4周后两组基本痊愈率分别为47.37%、18.42%，有效率分别为84.21%、34.21%，两组比较差异有统计学意义(P<0.01).治疗组无不良反应发生，对照组不良反应发生率为7.89%.结论：复方丙酸氯倍他索软膏治疗苔藓样皮肤淀粉样变病安全、有效.%　　Objective:Toevaluatetheefficacyandreliabilityofclobetasolpropionatecompoundointmentforthetreatmentoflichenoidamyloidosis.Methods:38patientswithlichenoidamyloidosiswhoselesiondistributedintwoshanksymmetricallywereselectedandtreatedforfourweeks,andtheleftshank(treatmentgroup)wastreatedwithclobetasolpropionatecompoundointmenttherapy,therightone(controlgroup)with0.025%all-trans-retinoicacidcream.Results:Thecurativerateswere47.37%fortreatmentgroupand18.42%forcontrolgroup.Theefficacyrateswere84.21%and34.21%,respectively,therewerestatisticaldifferenceintreatmentgroupandcontrolgroup(P<0.01)inthecurativeratesandefficacyrates.Inthetreatmentgroupsnonesideeffectswasfoundandsideeffectswerefoundin7.89%patientsofcontrolgroup.Conclusion:Clobetasolpropionatecompoundointmentisaneffectiveandsafetyagentforthetreatmentoflichenoidamyloidosis.