卡络磺钠与止血敏在前列腺电切术后的止血疗效比较

摘要

目的：比较卡络磺钠与止血敏(酚磺乙胺)在经尿道前列腺电切术后的止血疗效.方法：苏州市市立医院北区泌尿外科以2008年7月-2012年7月期间收治的60例行前列腺电切手术后尿道出血的前列腺增生患者为研究对象.60例患者随机分为两组,各30例,分别于术后静脉滴注卡络磺钠或止血敏,2次/d,连续5 d.观察患者用药后的血尿评分、止血效果、毒副作用及不良反应.结果：卡络磺钠和止血敏治疗后,患者的血压、脉搏、呼吸、肝功能、肾功能、血常规、出凝血时间、血小板均无显著改变；治疗3 d后,卡络磺钠组血尿评分下降,和止血敏组相比,差异具有统计学意义(P<0.05)；卡络磺钠在显效率方面显著高于止血敏(P<0.05).结论：对于经尿道前列腺电切术治疗前列腺增生所引起的尿道出血,卡络磺钠用药安全、止血迅速、效果显著,综合疗效显著优于同类产品止血敏.%　　Objective:To compare the hemostatic efficacy of carbazochrome sodium sulfonate and etamsylate after transurethral resection of Prostate(TURP).Methods:60 patients with benign prostatic hyperplasia (BPH) post TURP therapy in Suzhou Municipal Hospital during a period from Jul 2008 to Jul 2012 were randomized into two groups at 30 patients per group,T group and C group.Patients in both T group and C group were given intravenously with carbazochrome sodium sulfonate and etamsylate by BID for 5 consecutive days,respectively.Scoring hematuria,evaluating hemostatic efficacy,and observing side effects and adverse reactions were carried out post hemostatic’s treatment.Results:No significant changes in blood pressure,pulse,respiratory,liver function,kidney function,hemogram,clotting time,platelet profile observed post treatment of both hemostatics.Significant decreases in hematuria score for T group was observed when compared to the C group at least 3-day post treatment and significant hemostatic efficacy in T group was observed when compared to the C group(P<0.05).Conclusion:It is concluded carbazochrome sodium sulfonate achieves higher efficiency and efficacy in hemostasia than etamsylate for BPH patients post TURP therapy.