曲美他嗪治疗老年冠心病78例疗效观察

摘要

Objective:To investigate the clinical efficacy of Trimetazidine in the treatment of elderly patients with coronary heart disease,and compare with the clinical efficacy of Isosorbide Mononitrate Tablets,in order to provide basis for clinical treatment of senile coronary heart disease.Method:90 patients who consistent with the diagnosis of chronic stable angina standard admitted to our hospital from January 2009 to January 2011 were selected,they were divided into the Trimetazidine group and the Isosorbide Dinitrate Tablet group according to the random number table method,45 cases in each group.On the basis of conventional therapy,the Trimetazidine group was given Trimetazidine Dihydrochloride Tablets for treatment,the Isosorbide Dinitrate Tablet group was given Isosorbide Mononitrate Tablets for treatment,a treatment course was 3 month.After 3 months of treatment,the data of angina pectoris attack time,frequency and ECG changes in the two groups were statistically analyzed,the clinical effect and electrocardiogram efficacy between the two groups were observed and compared. Result:After treatment,the total effective rate of Trimetazidine group was 82.22%,it was significantly higher than 57.78%of Isosorbide Dinitrate Tablet group, and the total effective rate of electrocardiogram in Trimetazidine group was 77.78%,it was significantly higher than 51.11%of Isosorbide Dinitrate Tablet group, the differences were statistically significant(P<0.05).The two groups were no adverse reaction during the treatment period.Conclusion:Trimetazidine is a new type of treatment of senile coronary heart disease,its curative effect is obviously superior to the traditional drug treatment,is a new choice for clinical treatment of senile coronary heart disease medication,is worthy of clinical widely promotion.%目的：探讨盐酸曲美他嗪治疗老年冠心病患者的疗效，并与单硝酸异山梨酯片的治疗效果进行对比，以期为临床治疗老年冠心病提供依据。方法：选取笔者所在医院2009年1月-2011年1月收治的符合慢性稳定型心绞痛诊断标准的90例患者，按照随机数字表法将其分为曲美他嗪组和硝酸异山梨酯片组各45例。在常规治疗的基础上，曲美他嗪组加用盐酸曲美他嗪片治疗，硝酸异山梨酯片组加用单硝酸异山梨酯片治疗，3个月为一疗程。治疗3个月后，分别统计两组患者的心绞痛发作时间、发作的频率及心电图改变资料，并对所得数据进行统计学分析，观察比较两组患者的临床疗效和心电图疗效。结果：经治疗后，曲美他嗪组的治疗总有效率82.22%明显高于硝酸异山梨酯片组的57.78%，心电图总有效率77.78%明显高于硝酸异山梨酯片组的51.11%，差异均有统计学意义(P<0.05)。两组治疗期间均未发生不良反应。结论：曲美他嗪是一种新型的治疗老年冠心病的药物，其治疗效果明显优于传统的治疗药物，是临床治疗老年冠心病用药的一个新选择，值得临床广泛推广。