鼻咽癌患者血清乳酸脱氢酶检查的临床意义

摘要

Objective:To analyze the clinical effective of detection of serum lactate dehydrogenase patients with nasopharyngeal carcinoma.Method:352 patients with nasopharyngeal carcinoma in our hospital were selected as subjects and received serum lactate dehydrogenase detection, which were compared with the results of healthy people’s.Result:The serum LDH level of patients with nasopharyngeal carcinoma was significantly higher than this of healthy peoples’s,and the LDH level would came significantly higher with the progress of nasopharyngeal carcinoma(P<0.05).The patients which serum LDH level lower than 190 IU/L had 89.6% five year survival rate,which was larger than this of patients with serum LDH level higher than 190 IU/L before treatment(P<0.05).Conclusion:Serum LDH detection before treatment is very useful for early diagnosis and assessment of nasopharyngeal.%目的：分析鼻咽癌患者治疗前血清乳酸脱氢酶水平与鼻咽癌分期及其预后的关联性。方法：回顾性调查2002-2009年笔者所在医院放疗科收治的352例鼻咽癌患者，记录患者治疗前的临床特征及血清LDH水平，并与健康人进行比较。结果：鼻炎癌患者LDH水平显著性高于健康人(P<0.05)，并且随着癌症的进展，LDH水平显著升高(P<0.05)。治疗前血清LDH水平≤190 IU/L患者5年存活率为89.6%，显著性高于>190 IU/L患者(字2=147.747，P<0.05)。结论：血清LDH水平的测定对鼻咽癌患者的早期诊断和预后评估、监测有重要的临床意义。