产前抗梅毒治疗对妊娠梅毒患者妊娠结局及新生儿预后的影响

摘要

目的：研究产前抗梅毒治疗对妊娠梅毒患者妊娠结局及新生儿预后的影响，探讨产前抗霉素治疗的实际效果。方法：选取2010年8月-2012年9月在本院治疗的80例妊娠梅毒患者，根据产前是否接受抗梅毒治疗，分为观察组和对照组，各40例。监测比较两组妊娠梅毒患者的妊娠结局状况、围产儿预后及新生儿先天梅毒常规检查情况。结果：观察组产妇早产率、死产率、流产率、足月分娩率(5.0%、2.5%、0、92.5%)均优于对对照组产妇(25.0%、32.5%、15.0%、27.5%)，差异有统计学意义(P<0.05)；两组新生儿的预后比较，观察组各项数据统计均优于对照组，差异有统计学意义(P<0.05)。结论：在孕期应该做常规检查，做好早期的梅毒血清筛查工作，早发现早治疗，尽早的治疗梅毒能够有效降低新生儿的先天性梅毒发生率，改善妊娠结局。%Objective:To study the antenatal syphilis treatment in pregnant syphilis patients to the influence of the pregnancy outcome and neonatal prognosis,and explore the prenatal high treatment effect.Method:Selected during August 2010 to September 2012,the 80 cases of syphilis in pregnancy patients treated in our hospital,according to whether the prenatal resistance syphilis treatment,were divided into observation group and control group,40 patients in each group.Monitored and compared the two groups pregnancy outcomes of pregnancy patients with syphilis situation,perinatal prognosis and neonatal congenital syphilis routine inspection.Result:The preterm birth rate,stillbirth rate,miscarriage rate and full-term births rate(5.0%,2.5%,0,92.5%) of observation group maternal were better than the control group in maternal(25.0%,32.5%,15.0%,27.5%),the difference were statistically significant(P<0.05).Two groups of neonatal prognosis for comparison,the statistical observation group were better than control group,difference had statistical significance(P<0.05).Conclusion:During pregnancy shall do routine check,do a good job early syphilis serum screening,early found early treatment,early treatment of syphilis can effectively reduce the incidence of neonatal congenital syphilis,and improve pregnancy outcome.