补充维生素D3对缺血性心力衰竭患者心功能的临床作用

摘要

Objective:To explore positive clinical significance ot no of the vitamin D3 supplementation on heart function of patients with ischemic heart failure.Method:54 patients with ischemic heart failure in our hospital department of Cardiology from April 2013 to November 2013 were collected, and these patients were randomly divided into two groups.The treatment group was 27 cases,since the beginning of the hospitalized,in addition to the conventional treatment of heart failure,every patient complemented Vitamin D3 1000 IU,27 cases of heart failure patients in the control group only received routine treatment of heart failure.The in-hospital mortality rate,the left ventricular ejection fraction value and BNP level of the patients in the two groups at admission and discharge were calculated.After 3 months of follow-up,the readmission rate of patients in two groups was calculated.EF value, the level of BNP and the content of serum 25(OH)D3 were detected in outpatients.Result:It had no significant difference in hospital mortality,EF value and BNP level at discharge between the treatment group and the control group(P>0.05),but the former had a significantly lower readmission rate than the latter(P<0.05).After 3 months,the content of serum 25(OH)D3 of the treatment group was obviously higher than that of the control group(P<0.001);cardiac function indexes of the former were obviously improved than the latter(P<0.05).Conclusion:Taking vitamin D3 supplements moderately may correct the deficiency of vitamin D status,and obviously improve the cardiac function of patients with ischemic heart failure,moreover it can reduce the readmission because of heart failure.%目的：探究补充维生素D3对于缺血性心力衰竭患者的心脏功能有无积极的临床作用。方法：选取笔者所在医院心内科病房2013年4-11月收治的缺血性心力衰竭患者54例，随机将其分为两组。其中治疗组27例，自收住院开始，在常规的抗心力衰竭及对症治疗外，每天额外补充维生素D31000 IU；对照组中的27例心力衰竭患者只接受常规的抗心力衰竭及对症治疗。观察两组患者住院期间死亡率、入院时及出院时的左心室射血分数EF值、B型脑钠肽(BNP)水平。随访3个月，统计两组患者再入院率以及出院3个月后门诊复查EF、BNP，检测复查患者血清25(OH)D3。结果：两组患者住院死亡率、出院时EF值、BNP比较差异无统计学意义(P>0.05)，但随访期间治疗组再入院率明显低于对照组(P<0.05)。3个月后门诊复查时治疗组的血清25(OH)D3显著高于对照组(P<0.001)；前者心脏功能指标较后者改善明显(P<0.05)。结论：适当补充维生素D3可纠正维生素D3缺乏状态，同时明显改善缺血性心力衰竭患者的心脏功能，可减少患者因心力衰竭的再入院。