AFP与AFP-L3（）阳性率在原发性肝癌诊断中的价值

摘要

Objective:To investigate the relationship between the positive rate of alpha-fetoprotein variant 3[AFP-L3(%)] and the incidence of primary liver cancer(PHC) under different alpha fetal protein(AFP),and to provide a reference for clinical diagnosis of primary liver cancer.Method:According to the random number table method,240 cases were randomly selected in our hospital from July 2013 to June 2014,hospitalization and outpatient medical. AFP and AFP-L3 levels were detected in all patients,calculated the percentage of AFP-L3,that is,AFP-L3/AFP(%).Test results according to the AFP concentration range points into negative group(00.05).Conclusion:Detection of low concentration and high concentration of AFP in patients with AFP-L3(%) positive rate for the diagnosis of PHC has a certain clinical significance.%目的：探讨在不同甲胎蛋白(AFP)浓度下，甲胎蛋白异质体3百分比[AFP-L3(%)]阳性率与原发性肝癌(PHC)发病率之间的关系，为临床原发性肝癌的诊断提供参考。方法：按随机数字表法随机选取2013年7月-2014年6月在笔者所在医院门诊、住院及体检患者240例。检测所有患者的 AFP 和 AFP-L3含量，计算 AFP-L3百分比，即 AFP-L3/AFP(%)；将检测结果按 AFP 浓度范围分为阴性组(0≤AFP<10 ng/ml)、低浓度组(10 ng/ml≤AFP<400 ng/ml)和高浓度组(AFP≥400 ng/ml)，以 AFP-L3(%)≥10%为阳性标准，计算各组患者的 AFP-L3(%)阳性率；同时随访所有患者临床诊断结果，计算各组 PHC 的发病率。结果：AFP 浓度为阴性、低浓度和高浓度时，AFP-L3(%)阳性率分别为0、27.6%和38.5%，患者原发性肝癌发病率分别为0.9%、30.3%和40.4%。低浓度组、高浓度组与阴性组的 AFP-L3(%)阳性率及 PHC 发病率比较，差异均有统计学意义(P<0.05)；低浓度组与高浓度组 AFP-L3(%)阳性率及 PHC 发病率比较，差异均无统计学意义(P>0.05)。结论：检测低浓度和高浓度 AFP 患者AFP-L3(%)阳性率对 PHC 的诊断具有一定的临床意义。