血清NGAL和Cystatin C检测对糖尿病肾病早期诊断的对比研究

摘要

Objective:To compare the effect of serum NGAL and Cystatin C detection in the early diagnosis of diabetic nephropathy.Method:88 patients with type 2 diabetes were selected as the observation group,88 healthy people were selected as the control group,serum NGAL and Cystatin C content were measured rseparately,the two groups were compared and made the relevant analysis.Result:(1)The serum NGAL and Cystatin C of the observation group were significantly better than the control group,the eGFR index was significantly lower than the control group,the differences were statistically significant(P<0.01);(2) lnNGAL negative correlation with eGFR,correlation coefficient was -0.8412,superior Cystatin C(correlation coefficient of -0.7189).Conclusion:Serum NGAL in the early diagnosis of diabetic nephropathy is better than Cystatin C,and it can be used for early diagnosis of clinical.%目的：比较血清NGAL和Cystatin C检测对糖尿病肾病早期诊断效果。方法：选取88例2型糖尿病患者为观察组，88例健康人为对照组，分别测量其血清NGAL和Cystatin C含量，对两组进行比较和相关性分析。结果：(1)观察组患者血清NGAL和Cystatin C均显著高于对照组， eGFR指标显著低于对照组，两组比较差异均有统计学意义(P<0.01)；(2)lnNGAL与eGFR成负相关，相关系数为-0.8412，优于Cystatin C(相关系数为-0.7189)。结论：血清NGAL对糖尿病肾病早期诊断效果优于Cystatin C，可用于临床上的早期诊断。