[Objective]To optimize the ultrasonic extraction technology of cottonseed oil by response surface methodology.[Method]Based on the single factor experiment,the response surface method with three factors at three levels was adopted according to the principle of central composite design.The optimum extraction conditions of extraction duration,liquid-solid ratio and temperature were determined by regression analysis.[Result]The best ultrasonic extraction conditions of cottonseed oil were 35 min of extraction duration,38℃ of extraction temperature and 56:6 of liquid-solid ratio.Under these conditions,the extraction rate of cottonseed oil could reach up to 45.81%,with a relative error of 0.13% from the theoretical value of 45.94%.[Conclusion]The method optimized the extraction technology and laid foundation for the further research of cottonseed oil.
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