泼尼松联合汉方己甲素治疗特发性肺纤维化的临床研究

摘要

目的：探讨泼尼松联合汉方己甲素(TET)治疗特发性肺纤维化(IPE)的临床效果。方法：收治IPF患者50例，分为对照组25例，单用泼尼松；联合组25例，在泼尼松基础上加用 TET 口服。结果：联合组治疗后6个月 VC%pred、DLco%pred、PO2明显改善，呼吸困难评分明显下降，血清 HA、LN、PC-Ⅲ、IV-C 含量明显下降(P＜0.05)。结论：与单用泼尼松治疗相比，泼尼松联合TET可进一步改善IPF的治疗效果。%Objective:To investigate the clinical effect of prednisone combined with TET in the treatment of idiopathic pulmonary fibrosis.Methods:50 patients with IPF were selected.They were divided into the control group with 25 cases,and they were given prednisone alone.The united group with 25 cases,and they were given TET oral on the basis of prednisone.Results:The VC%pred, DLco% pred,PO2 of the united group were improved significantly after treatment for 6 months;the dyspnea scores decreased significantly,the serum HA,LN,PC- Ⅲ,IV-C content were decreased significantly(P<0.05).Conclusion:Compare with the prednisone alone treatment,prednisone combine with TET can further improve the therapeutic effect of IPF.