齐拉西酮与利培酮对首发男性精神分裂症患者血脂的影响

摘要

Objective:To explore the effect of ziprasidone and risperidone on the blood lipid of first-episode male patients with schizophrenia.Methods:100 first-episode male patients with schizophrenia were randomly divided into the ziprasidone group and the risperidone group with 50 cases in each.Before treatment and at 4,8,12 weeks of treatment,the blood lipid levels of patients were compared between the two groups.Results:At 4,8,12 weeks of treatment,the ziprasidone group and the risperidone group all had effect on the each indicators of blood lipid.But with the extension of the treatment,the increased value had a downward trend, and the ziprasidone group had less increased effect,it had significant difference(P<0.05).Conclusion:The ziprasidone and risperidone all have effects on the blood lipid of first-episode patients with schizophrenia,but the effect of ziprasidone is lighter.%目的：探讨齐拉西酮与利培酮对首发男性精神分裂症患者血脂的影响。方法：将100例首发男性精神分裂症患者随机分为齐拉西酮组和利培酮组各50例。于治疗前及治疗第4、8、12周，对两组患者的血脂水平进行比较。结果：齐拉西酮组与利培酮组对血脂各项指标在治疗第4、8、12周均有影响，但是随着治疗的延长，升高的值有下降趋势，且齐拉西酮组升高值较小，差异具有统计学意义(P＜0.05)。结论：齐拉西酮与利培酮对首发精神分裂症患者血脂均有影响，但齐拉西酮的影响较轻。