帕罗西汀治疗脑卒中后抑郁症的临床研究

摘要

目的：探讨帕罗西汀治疗脑卒中后抑郁症的临床疗效。方法：2009年1月-2014年3月收治脑卒中后抑郁患者80例，随机分为治疗组和对照组，每组40例。对照组应用常规神经系统药物抗抑郁治疗，治疗组在对照组治疗的基础上口服帕罗西汀20 mg/d治疗，4周1个疗程。治疗前后行HAMD和临床神经功能缺损程度(CSS)评分。结果：经过4周的治疗后，治疗组缓解抑郁效果显著优于对照组，差异具有统计学意义(P＜0.01)。两组治疗后HAMD与临床神经功能缺损(CSS)评分结果均明显改善，差异具有统计学意义(P＜0.01)。结论：帕罗西汀应用于脑卒中后抑郁的治疗，可以有效缓解患者的焦虑情绪，改善患者的抑郁症状，在促进患者神经功能、认知功能和日常生活能力的恢复方面具有良好的效果，不良反应少，是治疗卒中后抑郁症的理想药物。%Objective:To explore the clinical effect of paroxetine in the treatment of post-stroke drepression.Methods:80 cases of patients with post-stroke drepression from January 2009 to March 2014 were randomly divided into the treatment group and the control group,with 40 cases in each group.The patients of control group were given antidepressant treatment with regular nervous system drugs,the patients of treatment group were given oral paroxetine 20 mg/d treatment on the basis of the control group,4 weeks for a period of treatment.The HAMD and clinical nerve function defect degree (CSS) score were evaluated before and after the treatment.Results:After 4 weeks of treatment,the depression effect of the treatment group alleviated significantly better than that of the control group,the difference was statistically significant(P<0.01).The Two HAMD and clinical nerve function defect(CSS) score of the two groups after treatment were significantly improved,and the differences were statistically significant(P<0.01).Conclusion:Paroxetine used in the treatment of post-stroke drepression could alleviate the patient's anxiety effectively,improve the depression symptoms of patients,and had effect on promoting patients' nerve function,the recovery of cognitive function and daily life ability aspect,and less adverse reaction,which was an ideal drug for the treatment of post-stroke depression.