慢性阻塞性肺疾病合并骨质疏松患者血清MMP-9、TNF-α与骨代谢异常的相关性研究

摘要

目的：分析研究慢性阻塞性肺疾病合并骨质疏松患者血清 MMP-9、TNF-α与骨代谢异常的相关性。方法：2013-2014年收治慢性阻塞性肺疾病合并骨质疏松患者60例，分为骨质疏松组、骨密度减低组以及骨密度正常组，每组20例，实行酶联免疫吸附试验法来检测各组患者血清 MMP-9、TIMP-1、TNF-α，并且测算 MMP-9/TIMP-1的值。结果：骨密度正常组、骨密度减低组以及骨质疏松组患者的血清 MMP-9分别为(33.5±7.1)μg/L、(49.2±6.2)μg/L、(84.6±6.2)μg/L，TNF-α分别为(30.6±10.2)μg/L、(35.2±6.2)μg/L、(40.1±5.6)μg/L， MMP-9/TIMP-1的值分别为(0.20±0.05)、(0.28±0.11)、(0.45±0.13)，并且3组患者随着骨密度的降低，MMP-9、TNF-α、MMP-9/TIMP-1呈升高趋势，差异具有统计学意义(P＜0.05)。而3组患者在TIMP-1差异较小，无统计学意义(P＞0.05)。结论：慢性阻塞性肺疾病合并骨质疏松患者的骨代谢异常和血清 MMP-9、TNF-α具有相关性，并且骨质密度越低，血清MMP-9、TNF-α越高。所以血清MMP-9、TNF-α可能在慢性阻塞性肺疾病合并骨质疏松患者中发挥作用，促使患者骨密度下降并导致患者骨代谢异常，应当加强临床上的干预治疗。%Objective:To analyze and study the correlation of serum MMP-9,TNF-αand bone metabolic abnormalities in chronic obstructive pulmonary disease patients with osteoporosis.Methods:60 chronic obstructive pulmonary disease patients with osteoporosis were selected from 2013 to 2014.They were divided into the osteoporosis group,the bone density reducing group and the bone density normal group with 20 cases in each.The serum MMP-9,TIMP-1 and TNF-α of patients in each group were detected by enzyme-linked immunosorbent assay,and MMP-9/TIMP-1 value was calculated.Results:The serum MMP-9 of the bone density normal group,the bone density reducing group and the osteoporosis group were respectively (33.5 ± 7.1) μ g/L、(49.2±6.2)μg/L、(84.6±6.2)μg/L;TNF-α were respectively (30.6±10.2)μg/L、(35.2±6.2)μg/L、(40.1±5.6) μg/L;MMP-9/TIMP-1 value were respectively (0.20±0.05)、(0.28±0.11)、(0.45±0.13).And the patients of three groups with the loss of bone density,MMP-9,TNF-α,MMP-9/TIMP-1 showed an increasing trend,and the difference was statistically significant(P<0.05).And the patients of three groups had small differences in TIMP-1,and the difference was not statistically significant (P>0.05).Conclusion:The bone metabolic abnormalities of chronic obstructive pulmonary disease patients with osteoporosis has correlation with serum MMP-9,TNF-α,and bone density is lower.The serum MMP-9,TNF-α is higher.So the serum MMP-9,TNF-α may play a role in chronic obstructive pulmonary disease patients with osteoporosis,promote the bone density loss of patients and lead bone metabolic abnormalities of patients.We should strengthen clinical intervention treatment.