短暂性脑缺血发作及发展为脑梗死患者血清Hcy、hsCRP、Lp（a）水平分析

摘要

目的：探讨短暂性脑缺血发作(TIA)及发展为脑梗死患者血清同型半胱氨酸(Hcy)和脂蛋白[Lp(a)]、超敏C反应蛋白(hsCRP)含量变化的临床意义。方法：收治TIA患者66例。检测生化指标Hcy、hsCRP、Lp(a)水平，与30例正常健康体检者对照比较。结果：TIA组Hcy与hsCRP、Lp(a)的含量均高于健康对照组(P＜0.01)。TIA进展为脑梗死患者血清Hcy和hsCRP、Lp(a)的含量均高于无梗死者(P＜0.05)。结论：TIA患者血清Hcy、hsCRP、Lp(a)水平升高，三者共同作用，促进动脉粥样硬化斑块形成，从而进展为脑梗死。%Objective:To explore the clinical significance of the changes of serum homocysteine,lipoprotein and high sensitive C reactive protein in patients with cerebral infarction after transient ischemic attack.Methods:66 patients with transient ischemic attack were selected. Biochemical indicators Hcy,hsCRP,Lp(a) levels were detected.30 cases of normal healthy physical examination were compared.Results:The levels of Hcy,hsCRP and Lp(a) in patients with transient ischemic attack were higher than those in healthy control group(P<0.01).The levels of serum Hcy,hsCRP and Lp(a) in the patients with cerebral infarction were higher than those without the stem(P<0.05).Conclusion:The serum levels of Hcy,hsCRP,Lp(a) were increased in patients with TIA,and the three were combined together to promote the formation of atherosclerotic plaque,which was the development of cerebral infarction.