雄激素受体对乳腺癌细胞增殖及相关分子表达作用的研究进展∗

摘要

Breast cancer is known as a hormone⁃responsive cancer. Apart from estrogen,androgen also plays a critical role in the occurrence and development of breast cancer. The binding of androgen to androgen receptor( AR) leads to the activation of AR, which interacts with molecules in the nuclear, resulting in up⁃regulation or down⁃regulation of target proteins. AR is associated with the expression of ERs, aromatase, human epidermal growth factor receptor⁃2(HER⁃2), progesterone receptor(PR) and E⁃cadherin. The resistant mechanisms of aromatase inhibitions(AIs) and selective estrogen receptor modulators(SERMs) Tamoxifen are also relevant with AR. Further investigation of AR signaling makes it possible to be an effective therapeutic target for breast cancer.%乳腺癌是激素依赖性肿瘤。除雌激素外，雄激素在乳腺癌的发生发展中也发挥重要作用。雄激素受体（ AR）经雄激素作用激活，通过不同方式调控雌激素受体（ ER）及芳香化酶的表达，影响人表皮生长因子受体⁃2（ HER⁃2）、孕激素受体（ PR）、E⁃钙黏蛋白的转录，对乳腺癌细胞的增殖既有抑制也有促进作用。 AR还与雌激素受体调节剂（ SERMs）他莫昔芬及芳香化酶抑制剂（ AIs）的耐药机制有关。深入研究AR调控乳腺癌分子表达的机制有助于将AR作为治疗靶点，提高乳腺癌内分泌治疗的疗效。