子宫腺瘤样瘤110例临床病理分析

摘要

Objective To investigate the clinicopathological features of uterine adnomatoid tumors in order to improve the di⁃agnostic level of this disease. Methods The clinical and pathological data of 110 adenomatoid tumors of uterus in Changzhou Second People�s Hospital Affiliated to Nanjing Medical University from January 2008 to December 2015 were collected to analyze the clinico⁃pathological characteristics. Results Uterine adnomatoid tumors accounted for 1�55% in the contemporaneous hysterectomy and uterus⁃preserving tumor excision specimen. The clinical manifestations were not specific. A total of 109 cases located in the myometri⁃um, one case located in subserous. Microscopically, the tumors were arranged in gland⁃like, microcystic, trabecular, solid patterns with flat, cuboidal, epithelialoid tumor cells. Immunohistochemical staining showed tumor cells were positive for CK, Vim, HBME⁃1, D2⁃40, Calretinin, WT⁃1, but negative for CD34, EMA. Conclusion Uterine adenomatoid tumor is not rare and easy to be misdiag⁃nosed in clinical and pathological examination. Immunohistochemistry plays an important role in diagnosis and differential diagnosis of this disease.%目的：探讨子宫腺瘤样瘤的临床病理特点，以提高子宫腺瘤样瘤的诊断水平。方法对南京医科大学附属常州第二人民医院2008年1月至2015年12月收治的110例子宫腺瘤样瘤患者的手术组织标本进行临床病理及免疫组织化学观察，分析其临床及病理学特征。结果110例子宫腺瘤样瘤占同期子宫切除或子宫肿瘤剥除标本的1�55％，患者临床表现无特异性。109例位于肌层，1例位于浆膜下。镜下肿瘤排列成腺管样、微囊状、梁状、实性结构，肿瘤细胞扁平、立方状或上皮样。免疫组化染色显示，肿瘤细胞CK、Vim、HBME⁃1、D2⁃40、Calretinin、WT⁃1阳性表达，CD34、EMA不表达。结论子宫腺瘤样瘤并不罕见，但临床和病理组织学均易误诊。免疫组化可作为诊断和鉴别诊断的重要参考依据。