Objective: To summarize the short-term clinical experience of minimally invasive direct cardiac surgery (MIDCS) with right anterolateral thoracotomy incision by closed cardiopulmonary bypass. Methods: A total of 42 patients received MIDCS in our hospital from 2013-09 to 2015-05 were summarized. There were 18 male and 24 female patients including 16 with atrial septal defect (ASD) repair, 4 with ventricular septal defect (VSD) repair, 16 with mitral valve replacement (MVR), 1 with mitral valve plasty (MVP) and 5 with aortic valve replacement (AVR). Direct cardiac surgery was performed by cardiopulmonary bypass through femoral artery-vein and right jugular vein annulations. A right anterolateral thoracotomy incision (length 3-5 cm) was made to enter the chest and complete the operation. Results: All 42 patients received successful operation, no peri-operative or early post-operative death, no incision infection occurred. Cardiopulmonary bypass time was [98-142 (122.4 ± 23.7) min], aortic cross-clamp time [0-118 (48.3 ± 26.2) min]. Post-operative mechanical ventilation time was [8-76 (17.4±13.1) h], intensive care unit stay time [45-124, (54.6 ± 32.6) h], hospital stay time [6-12, (8.2 ± 1.3) d]. Incision length was [3-7, (4.8 ± 1.5) cm], the draining volume at the 1st post-operative day was (356.9 ± 283.8) ml and there were 27 (64.3%) patients without transfusion. Conclusion: The short-term outcomes for MIDCS were good, it with superior safety, broad application range with minimal invasion and less complication.%目的：总结微创直视心脏外科手术（MIDCS）的近期临床效果。方法：2013-09至2015-05我院完成MIDCS 42例，其中男18例，女24例。房间隔缺损修补术16例，室间隔缺损修补术4例，二尖瓣置换术16例，二尖瓣成形术1例，主动脉瓣置换术5例。直视心脏外科手术方法为股动、静脉及右颈静脉插管行体外循环，双腔气管插管。做右胸前外侧切口3~5 cm，经肋间入胸腔，剪开心包，进入心腔完成手术。结果：42例患者全部手术成功，无围手术期及出院后近期死亡，无胸骨切口感染。体外循环时间98~142 min，平均（122.4±23.7）min；主动脉阻断时间0~118 min，平均（48.3±26.2）min。术后气管插管时间8~76 h，平均（17.4±13.1）h，监护时间45~124 h，平均（54.6±32.6）h；术后住院时间6~12 d，平均（8.2±1.3）d。患者切口长度3~7 cm，平均(4.8±1.5) cm；术后第1天引流量(356.9±283.8) ml，未输血患者27例(64.3％)。结论： MIDCS近期效果好，手术安全性高，适用范围广；创伤小，并发症少，切口美观。
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