慢阻肺合并重症呼吸衰竭患者应用无创呼吸机治疗的临床效果观察

摘要

目的 分析慢性阻塞性肺疾病 (慢阻肺) 合并重症呼吸衰竭患者应用无创呼吸机治疗的临床效果.方法 113例慢阻肺合并重症呼吸衰竭患者, 根据治疗方式不同分为观察组 (56例) 和对照组 (57例) .对照组患者实施常规治疗, 观察组患者在对照组基础上实施无创呼吸机治疗.比较两组患者的治疗效果、治疗前后动脉血气水平及治疗前后炎性因子水平变化情况.结果 治疗后观察组患者的治疗总有效率为96.42％, 明显高于对照组的78.95％, 差异具有统计学意义 (P<0.05) .治疗后观察组患者的血氧分压 (PaO2) 及动脉血氧饱和度 (SaO2) 水平高于对照组, 血二氧化碳分压 (PaCO2) 低于对照组, 差异均具有统计学意义 (P<0.05) .治疗后观察组患者的白细胞介素 (IL) -10水平明显高于对照组、IL-18及肿瘤坏死因子-α (TNF-α) 水平明显低于对照组, 差异均具有统计学意义 (P<0.05) .结论 慢阻肺合并重症呼吸衰竭患者, 采用无创呼吸机治疗的效果较为理想, 能有效改善患者的呼吸障碍情况, 缩短患者治疗时间, 保证患者健康, 临床意义较为深远.%Objective To analyze the clinical effect of non-invasive ventilator therapy in patients with chronic obstructive pulmonary disease complicated with severe respiratory failure. Methods A total of 113 patients with chronic obstructive pulmonary disease complicated with severe respiratory failure were divided by different treatment methods into observation group (56 cases) and control group (57 cases) . The control group received conventional therapy, and the observation group received non-invasive ventilator therapy on the basis of the control group. Comparison were made on treatment effect, changes of arterial blood gas and inflammatory factors before and after treatment between the two groups. Results After treatment, the observation group had obviously higher total treatment effective rate as 96.42％ than 78.95％ in the control group, and the difference was statistically significant (P<0.05) . After treatment, the observation group had obviously higher partial blood oxygen pressure (PaO2) and arterial oxygen saturation (SaO2) than the control group. The observation group had lower blood partial pressure of carbon dioxide (PaCO2) than the control group, and the difference was statistically significant (P<0.05) . After treatment, the observation group had obviously higher interleukin (IL) -10 than the control group, and obviously lower IL-18 and tumor necrosis factor-α (TNF-α) levels than the control group. Their difference was statistically significant (P<0.05) . Conclusion For patients with chronic obstructive pulmonary disease complicated with severe respiratory failure, The effect of non-invasive ventilator treatment is ideal. It can effectively improve the respiratory disorders of patients, shorten their treatment time, and ensure their health. It has far-reaching clinical significance.