吉西他滨联合顺铂治疗晚期三阴乳腺癌的临床观察

摘要

目的：观察吉西他滨联合顺铂(GP方案)治疗蒽环类和紫杉类失败的晚期三阴乳腺癌近期疗效和毒副反应。方法30例晚期三阴乳腺癌患者给予吉西他滨1.0 g/m2静脉滴注第1、8天(30min内滴注完毕),顺铂75 mg/m2,分2 d静脉滴注(第1、2天),21 d为1周期,2周期后评价客观疗效。30例患者近期疗效 CR：0例, PR：11例(36.7%), SD ：12例(40%), PD ：7例(23.3%)；总有效率36.7%。该方案的主要毒副反应为胃肠道反应和骨髓抑制。结果疗效30例患者均完成2周期化疗,均可评价疗效,其中CR 0例, PR 11例(36.7%), SD例12(40%), PD7例(23.3%),有效率为36.7%。不良反应主要表现为消化道反应、骨髓抑制,无治疗相关性死亡。结论GP方案治疗晚期三阴乳腺癌具有良好的近期疗效,耐受性较好。%Objective To observe the efficacy and toxicity of gemcitabine(GEM) plus cisplatin(DDP) in the treatment of advanced TNBC after the failure of anthracyclines and taxanes.MethodsThere were 30 cases of advanced triple negative breast cancer(TNBC) with anthracyclines and taxanes resistance who were treated with GEM 1.0 g/m2, for 1st and 8th day and DDP 75mg/m2 intravenous drip in 2 days (1st and 2nd day)21days repeatedly. After 2cycles, the response and side effects were evaluated. All cases were followed up for more than 6 months.ResultsEfficacy of the 30 cases were as follows: PR 11 cases (36.7%), SD 12 cases(40%), PD 7 cases(23.3%), with a total rate of 36.7%. Myelosupression and gastrointestinal tract reaction were the most common toxicities.ConclusionThe combination of gemcitabine and cisplatin is effective and safe in treatment of advanced TNBC.