冠心病患者D-二聚体、血小板膜糖蛋白测定及临床分析

摘要

目的：探究冠心病患者血液中血小板膜糖蛋白(GP)和D-二聚体(D-D)的变化情况及临床意义。方法对37例不稳定型心绞痛(UA)患者(UA组),23例稳定型心绞痛(SA)患者(SA组)和30例正常人(对照组)体内的GP和D-D浓度进行检测,并对有无冠状动脉事件发生者之间的关系加以分析。结果UA组患者中GP和D-D浓度与SA组及对照组比较差异均有统计学意义(P<0.05)。有心血管事件发生组GP和D-D含量高于无心血管事件发生组,差异有统计学意义(P<0.05)。结论GP和D-D浓度能够当作冠状动脉血栓形成的重要指标,并可以在一定程度上将冠状动脉事件发生的危险性加以全面反映。%ObjectiveTo investigate changes and clinical significance of platelet membrane glycoprotein (GP) and D-dimer (D-D) in coronary heart disease patients.MethodsGP and D-D in 37 unstable angina (UA) patients (UA group), 23 stable angina (SA) patients (SA group) and 30 normal people (control group) were detected. Relationship between patients with and without coronary artery incident was analyzed.ResultsThere were statistically significant differences of GP and D-D between UA group and SA group, control group (P<0.05). The cardiovascular event group had higher GP and D-D levels than non-cardiovascular event group, and the difference had statistical significance (P<0.05).Conclusion Concentration of GP and D-D can be taken as important indexes for coronary arterial thrombosis, and they can fully reveal risk of coronary artery incident to a certain degree.