脑脊液C反应蛋白及免疫球蛋白对儿童感染性脑膜炎临床诊断的意义

摘要

Objective To investigate the application value of C-reactive protein (CRP) and immunoglobulin in the clinical diagnosis of infectious meningitis in children.Methods A total of 150 children with infectious meningitis were selected as the research group, while there were 50 healthy children as the control group. Related factors of CRP and immunoglobulin (IgA, IgM, IgG) in cerebrospinal fluid were detected in the two groups.Results The detection results of clinical biochemical criterions in the research group were all higher than those in the control group (allP<0.05). The level of IgG in viral meningitis group was higher than the other two groups (P<0.05). There was no statistically significant difference of CRP in the three infectious meningitis groups (P>0.05).Conclusion The detection of CRP and immunoglobulin can be used as the effective indicator for meningitis detection, and it has great application value in clinic.%目的：探讨C反应蛋白(CRP)及免疫球蛋白检测在儿童感染性脑膜炎临床诊断中的应用价值。方法150例感染性脑膜炎患儿作为研究组，同期健康儿童50例作为对照组，分别检测两组儿童的脑脊液CRP和免疫球蛋白(IgA、IgM、IgG)相关指标。结果研究组临床生化指标检测结果均高于对照组(均P<0.05)。结核性脑膜炎组IgA和IgM低于其他两组(P<0.05)；病毒性脑膜炎组IgG高于其他两组(P<0.05)；三种感染性脑膜炎患儿CRP间比较差异无统计学意义(P>0.05)。结论 C反应蛋白和免疫球蛋白检测可作为脑膜炎检测的有效指标，具有较大的临床使用价值。